Integrated Analysis of Copy Number Variations and Gene Expression Profiling in Hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the top three cancer killers worldwide. To identify CNV-driven differentially expressed genes (DEGs) in HBV related HCC, this study integrated analysis of copy number variations (CNVs) and gene expression profiling. Significant genes in regions of CNVs were overlapped with those obtained from the expression profiling. 93 CNV-driven genes exhibiting increased expression in the duplicated regions and 45 showing decreased expression in the deleted regions were obtained, which duplications and deletions were mainly documented at chromosome 1 and 4. Functional and pathway enrichment analyses were performed using DAVID and KOBAS, respectively. They were mainly enriched in metabolic process and cell cycle. Protein-protein interaction (PPI) network was cons

SUBMITTER: Zhou C 

PROVIDER: S-EPMC5585301 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature