Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.

ABSTRACT: The discovery of neuropeptides provides insights into the regulation of physiological processes. The precursor for the neuropeptide neuromedin U contains multiple consensus sequences for proteolytic processing, suggesting that this precursor might generate additional peptides. We performed immunoaffinity chromatography of rat brain extracts and consequently identified such a product, which we designated neuromedin U precursor-related peptide (NURP). In rat brain, NURP was present as two mature peptides of 33 and 36 residues. Radioimmunoassays revealed NURP immunoreactivity in the pituitary, small intestine, and brain of rats, with the most intense reactivity in the pituitary. Intracerebroventricular administration of NURP to both male and female rats robustly increased plasma concentration

SUBMITTER: Mori K 

PROVIDER: S-EPMC5585327 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature