Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology.

ABSTRACT: Cellular processes often depend on interactions between proteins and the formation of macromolecular complexes. The impairment of such interactions can lead to deregulation of pathways resulting in disease states, and it is hence crucial to gain insights into the nature of macromolecular assemblies. Detailed structural knowledge about complexes and protein-protein interactions is growing, but experimentally determined three-dimensional multimeric assemblies are outnumbered by complexes supported by non-structural experimental evidence. Here, we aim to fill this gap by modeling multimeric structures by homology, only using amino acid sequences to infer the stoichiometry and the overall structure of the assembly. We ask which properties of proteins within a family can assist in the predictio

SUBMITTER: Bertoni M 

PROVIDER: S-EPMC5585393 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature