Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches.

ABSTRACT:

Background

Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases. There is not much knowledge about is adult neurogenesis is or not modified in amyotrophy lateral sclerosis (ALS). All previous publications has studied the ALS SOD1 (superoxide dismutase) transgenic mouse model. The purpose of this study is to examine the process of adult neurogenesis in classic niches (subventricular zone [SVZ] and subgranular zone [SGZ] of the dentate gyrus) in patients with amyotrophic lateral sclerosis (ALS), both with (ALS-FTD) and without associated frontotemporal dementia (FTD).

Methods

We studied 9 autopsies of patients with ALS (including 2 with ALS-FTD) and 4 controls. ALS wa

SUBMITTER: Galan L 

PROVIDER: S-EPMC5585932 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature