Circadian disruption promotes tumor growth by anabolic host metabolism; experimental evidence in a rat model.

ABSTRACT:

Background

Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy metabolism, immune dysfunction and cancer. We hypothesized that constant light (LL) in rats may facilitate tumor growth via disrupted metabolism and increased inflammatory response in the host, inducing a propitious microenvironment for tumor cells.

Methods

Male Wistar rats were exposed to LL or a regular light-dark cycle (LD) for 5 weeks. Body weight gain, food consumption, triglycerides and glucose blood levels were evaluated; a glucose tolerance test was also performed. Inflammation and sickness behavior were evaluated after the administration of intravenous l

SUBMITTER: Guerrero-Vargas NN 

PROVIDER: S-EPMC5585981 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature