Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.

ABSTRACT:

Objectives

Molecular characteristics of hepatitis B virus (HBV), such as genotype and genomic mutations, may contribute to liver-related morbidity and mortality. The association of these characteristics with liver fibrosis severity in sub-Saharan Africa is uncertain. We aimed to characterise molecular HBV features in human immunodeficiency virus (HIV)/HBV co-infected Nigerians and evaluate associations between these characteristics and liver fibrosis severity before and after antiretroviral therapy (ART) initiation.

Methods

HIV/HBV co-infected Nigerians underwent liver fibrosis estimation by transient elastography (TE) prior to and 36 months after ART initiation. Basal core promoter/precore (BCP/PC) and preS1/preS2/S regions of HBV were sequenced from baseline plasma samples

SUBMITTER: Grant J 

PROVIDER: S-EPMC5586040 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature