Loxapine to control agitation during weaning from mechanical ventilation.

ABSTRACT:

Background

Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to establish whether loxapine would reduce MV weaning duration in agitated patients.

Methods

We performed a multicentre, double-blind, placebo-controlled, parallel group, randomised trial. Patients who were potential candidates for weaning but exhibited agitation (Richmond Agitation-Sedation Scale score ≥ 2) after sedation withdrawal were randomly assigned to receive either loxapine or placebo. In case of severe agitation, conventional sedation was immediately resumed. The primary endpoint was the time between first administration of loxapine or placebo and success

SUBMITTER: Gaudry S 

PROVIDER: S-EPMC5586048 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature