Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study.

ABSTRACT:

Background

Fracture risk is increased in chronic kidney disease (CKD), but assessment of bone fragility remains controversial in these patients. This study investigated the associations between bone turnover markers, bone mineral density (BMD), and prevalent fragility fracture in a cohort of kidney transplantation candidates.

Methods

Volumetric BMD of spine and hip was measured by quantitative computed tomography. Parathyroid hormone (PTH), bone-specific alkaline phosphatase, procollagen type-1 N-terminal propeptide, tartrate resistant alkaline phosphatase, and C- and N-terminal telopeptides of type 1 collagen were analyzed from fasting morning blood samples. Fragility fractures included prevalent vertebral fractures and previous low-trauma clinical fractures.

Results

SUBMITTER: Jorgensen HS 

PROVIDER: S-EPMC5586067 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature