Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans.

ABSTRACT:

Background/objectives

Elevated triglycerides predict insulin resistance and vascular disease in obesity, but how the inert triglyceride molecule is related to development of metabolic disease is unknown. To pursue novel potential mediators of triglyceride-associated metabolic disease, we used a forward genetics approach involving inbred mice and translated our findings to human subjects.

Subjects/methods

Hemopexin (HPX) was identified as a differentially expressed gene within a quantitative trait locus associated with serum triglycerides in an F₁₆ advanced intercross between the LG/J and SM/J strains of mice. Hpx expression was evaluated in both the reproductive fat pads and livers of mice representing three strains, LG/J (n=25), SM/J (n=27) and C57Bl/6J (n=19), o

SUBMITTER: Lawson HA 

PROVIDER: S-EPMC5586146 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature