Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium.

ABSTRACT: The development of nanomaterials for advanced therapies requires the formation of versatile platforms that may be tuned to maximize beneficial attributes and minimize unwanted negative behaviour. Additionally, the optimum route of administration is a key consideration of any new treatment and much work has been focused on direct injection into the systemic circulation rather than oral delivery. Here we describe a new approach to polymeric nanoparticle design and present initial results showing the potential for tuneable permeation through a gut epithelium model. Through the use of mixed initiators and branched vinyl polymerization, a series of systematically varying branched polymers have been synthesized and nanoprecipitated. The surprisingly uniform structures have undergone preliminary

SUBMITTER: Hatton FL 

PROVIDER: S-EPMC5586204 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature