Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.

ABSTRACT: Ageing drives changes in neuronal and cognitive function, the decline of which is a major feature of many neurological disorders. The hippocampus, a brain region subserving roles of spatial and episodic memory and learning, is sensitive to the detrimental effects of ageing at morphological and molecular levels. With advancing age, synapses in various hippocampal subfields exhibit impaired long-term potentiation, an electrophysiological correlate of learning and memory. At the molecular level, immediate early genes are among the synaptic plasticity genes that are both induced by long-term potentiation and downregulated in the aged brain. In addition to revitalizing other aged tissues, exposure to factors in young blood counteracts age-related changes in these central nervous system paramete

SUBMITTER: Castellano JM 

PROVIDER: S-EPMC5586222 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature