Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function.

ABSTRACT:

Background

Early evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of proteinuria with incident AF is altered by kidney function.

Methods and results

Retrospective cohort study using administrative healthcare databases in Ontario, Canada (2002-2015). A total of 736 666 patients aged ≥40 years not receiving dialysis and with no previous history of AF were included. Proteinuria was defined using the urine albumin-to-creatinine ratio (ACR) and kidney function by the estimated glomerular filtration rate (eGFR). The primary outcome was time to AF. Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow-up

SUBMITTER: Molnar AO 

PROVIDER: S-EPMC5586292 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature