Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation.

ABSTRACT:

Background

Diagnosis of atrial fibrillation (AF) can be difficult, requiring cumbersome investigations. We aimed to determine the association of established whole-blood gene expression scores with prevalent AF and to evaluate their performance for the identification of AF in a SIRS (Steroids in Cardiac Surgery) trial cohort.

Methods and results

Whole-blood, transcriptome-wide gene expression profiling was performed using the Illumina HumanHT-12 Expression BeadChip in 416 participants (65% men) before surgery, including 91 with a diagnosis of AF. An AF gene score (GS) calculated from 7 genes reported to be upregulated in AF and a validated GS for biological age based on 1254 genes related to aging were both independently associated with AF diagnosis before surgery in multivar

SUBMITTER: Theriault S 

PROVIDER: S-EPMC5586311 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature