Exact Calculation of the Joint Allele Frequency Spectrum for Isolation with Migration Models.

ABSTRACT: Population genomic datasets collected over the past decade have spurred interest in developing methods that can utilize massive numbers of loci for inference of demographic and selective histories of populations. The allele frequency spectrum (AFS) provides a convenient statistic for such analysis, and, accordingly, much attention has been paid to predicting theoretical expectations of the AFS under a number of different models. However, to date, exact solutions for the joint AFS of two or more populations under models of migration and divergence have not been found. Here, we present a novel Markov chain representation of the coalescent on the state space of the joint AFS that allows for rapid, exact calculation of the joint AFS under isolation with migration (IM) models. In turn, we show

SUBMITTER: Kern AD 

PROVIDER: S-EPMC5586375 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature