Contrasting Determinants of Mutation Rates in Germline and Soma.

ABSTRACT: Recent studies of somatic and germline mutations have led to the identification of a number of factors that influence point mutation rates, including CpG methylation, expression levels, replication timing, and GC content. Intriguingly, some of the effects appear to differ between soma and germline: in particular, whereas mutation rates have been reported to decrease with expression levels in tumors, no clear effect has been detected in the germline. Distinct approaches were taken to analyze the data, however, so it is hard to know whether these apparent differences are real. To enable a cleaner comparison, we considered a statistical model in which the mutation rate of a coding region is predicted by GC content, expression levels, replication timing, and two histone repressive marks. We ap

SUBMITTER: Chen C 

PROVIDER: S-EPMC5586376 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature