Vascular Endothelial Growth Factor and Ischemic Heart Disease Risk: A Mendelian Randomization Study.

ABSTRACT:

Background

Vascular endothelial growth factor (VEGF) has angiogenic and possibly proatherosclerotic properties. Observationally it is positively associated with cardiovascular disease, although these observations could be confounded or due to reverse causation. We assessed ischemic heart disease (IHD) risk by genetically predicted VEGF, ie, using Mendelian randomization.

Methods and results

Single nucleotide polymorphisms (SNPs) predicting VEGF level, at genome-wide significance, were applied to the CARDIoGRAMplusC4D 1000 Genomes-based genome-wide association study IHD case (n=60 801)-control (n=123 504) study. We obtained unconfounded estimates using instrumental variable analysis by combining the Wald estimates for each SNP using inverse variance weighting and Mendelian ra

SUBMITTER: Au Yeung SL 

PROVIDER: S-EPMC5586422 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature