A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.

ABSTRACT:

Background

Heart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood.

Methods and results

This study used a systems biology approach to investigate mechanisms underlying sex differences in cardiac hypertrophy. Male and female mice were treated for 2 and 3 weeks with angiotensin II to induce hypertrophy. Sex differences in cardiac hypertrophy were apparent after 3 weeks of treatment. RNA sequencing was performed on hearts, and sex differences in mRNA expression at baseline and following hypertrophy were observed, as well as within-sex differences between baseline and hypertrophy. Sex differences in mRNA were substantial at baseline and reduced somewhat

SUBMITTER: Harrington J 

PROVIDER: S-EPMC5586433 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature