OncoKB: A Precision Oncology Knowledge Base.

ABSTRACT:

Purpose

With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base.

Methods

OncoKB annotates the biological and oncogenic effect and the prognostic and predictive significance of somatic molecular alterations. Potential treatment implications are stratified by the level of evidence that a specific molecular alteration is predictive of drug response based on US Food and Drug Administration (FDA) labeling, National Comprehensive Cancer Network (NCCN) guidelines, disease-focused expert

SUBMITTER: Chakravarty D 

PROVIDER: S-EPMC5586540 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature