Randomized Controlled Trial for the Effect of Vitamin D Supplementation on Vascular Stiffness in CKD.

ABSTRACT:

Background and objectives

Vitamin D is implicated in vascular health in CKD. This study compared placebo, calcifediol, and calcitriol treatment with changes in vascular stiffness, BP, proteinuria, mineral metabolism parameters, C-reactive protein, and fibroblast growth factor 23 in patients with stable CKD.

Design, setting, participants, & measurements

We conducted a double-blind, randomized controlled trial in out-patient CKD clinics in Vancouver, Canada, from February of 2011 to August of 2014, enrolling 119 patients with an eGFR of 15-45 ml/min per 1.73 m². Change in pulse wave velocity (PWV) was measured after 6 months of treatment with a fixed dose of oral calcifediol (5000 IU 25-hydroxyvitamin D₃), calcitriol (0.5 µg 1,25-dihydroxyvitamin D

SUBMITTER: Levin A 

PROVIDER: S-EPMC5586581 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature