Fibroblast Growth Factor 23 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT:

Background and objectives

Increases in fibroblast growth factor 23 precede kidney function decline in autosomal dominant polycystic kidney disease; however, the role of fibroblast growth factor 23 in autosomal dominant polycystic kidney disease has not been well characterized.

Design, setting, participants & measurements

We measured intact fibroblast growth factor 23 levels in baseline serum samples from 1002 participants in the HALT-PKD Study A (n=540; mean eGFR =91±17 ml/min per 1.73 m²) and B (n=462; mean eGFR =48±12 ml/min per 1.73 m²). We used linear mixed and Cox proportional hazards models to test associations between fibroblast growth factor 23 and eGFR decline, percentage change in height-adjusted total kidney volume, and composit

SUBMITTER: Chonchol M 

PROVIDER: S-EPMC5586583 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature