Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep.

ABSTRACT:

Context

Obstructive sleep apnea (OSA) is associated with diabetes and cardiovascular disease. This association may be related to metabolic changes that transpire during sleep in OSA.

Objective

To examine the impact of OSA, elicited by cessation of continuous positive airway pressure (CPAP), on frequently sampled nocturnal metabolic markers including plasma free fatty acids (FFAs), glucose, insulin, triglycerides (TGs), cortisol, and lactate, as well as glucose production, oral glucose tolerance, blood pressure (BP), endothelial function, cholesterol, and high-sensitivity C-reactive protein (hsCRP).

Design and setting

Randomized crossover trial of CPAP vs CPAP withdrawal.

Patients

Thirty-one patients with moderate to severe OSA acclimated to CPAP.

Interventio

SUBMITTER: Chopra S 

PROVIDER: S-EPMC5587067 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature