Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia.

ABSTRACT:

Objective

Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL.

Methods

All eligible children with ALL who are (≤ 19) years old and receive 6-MP therapy for at least 1 month were approached to participate in the study. A total of 52 children with ALL and their primary caregivers were recruited. Adherence measures included an objective method (measuring 6-MP metabolites in packed Red Blood Cells (RBCs)) and a subjective method (using parent and child self-report via the Medication Adherence Report

SUBMITTER: Alsous M 

PROVIDER: S-EPMC5587295 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature