FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy.

ABSTRACT: FOXF1, a member of the forkhead box family of transcription factors, has been previously shown to be critical for lung development, homeostasis, and injury responses. However, the role of FOXF1 in lung regeneration is unknown. Herein, we performed partial pneumonectomy, a model of lung regeneration, in mice lacking one Foxf1 allele in endothelial cells (PDGFb-iCre/Foxf1 ^fl/+ mice). Endothelial cell proliferation was significantly reduced in regenerating lungs from mice deficient for endothelial Foxf1. Decreased endothelial proliferation was associated with delayed lung regeneration as shown by reduced respiratory volume in Foxf1-deficient lungs. FACS-sorted endothelial cells isolated from regenerating PDGFb-iCre/Foxf1 ^fl/+ and control lungs were used for RNAseq analys

SUBMITTER: Bolte C 

PROVIDER: S-EPMC5587533 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature