Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.

ABSTRACT: p53 encodes a transcription factor that transactivates downstream target genes involved in tumour suppression. Although osteosarcoma frequently has p53 mutations, the role of p53 in osteosarcomagenesis is not fully understood. To explore p53-target genes comprehensively in calvarial bone and find out novel druggable p53 target genes for osteosarcoma, we performed RNA sequencing using the calvarial bone and 23 other tissues from p53 ^+/+ and p53 ^-/- mice after radiation exposure. Of 23,813 genes, 69 genes were induced more than two-fold in irradiated p53 ^+/+ calvarial bone, and 127 genes were repressed. Pathway analysis of the p53-induced genes showed that genes associated with cytokine-cytokine receptor interactions were enriched. Three genes, CD137L, CDC42

SUBMITTER: Tsuda Y 

PROVIDER: S-EPMC5587585 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature