Proteogenomic Analysis and Discovery of Immune Antigens in Mycobacterium vaccae.

ABSTRACT: Tuberculosis (TB) is one of the leading causes of death worldwide, especially in developing countries. Neonatal BCG vaccination occurs in various regions, but the level of protection varies in different populations. Recently, Mycobacterium vaccae is found to be an immunomodulating therapeutic agent that could confer a significant level of protection against TB. It is the only vaccine in a phase III trial from WHO to assess its efficacy and safety in preventing TB disease in people with latent TB infection. However, the mechanism of immunotherapy of M. vaccae remains poorly understood. In this study, the full genome of M. vaccae was obtained by next-generation sequencing technology, and a proteogenomic approach was successfully applied to further perform genome annotati

SUBMITTER: Zheng J 

PROVIDER: S-EPMC5587859 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature