Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants.

ABSTRACT:

Objective

Development of the gastrointestinal tract and immune system can be modulated by the gut microbiota. Establishment of the intestinal microbiota, in its turn, is affected by host and environmental factors. As such, development of the gut microbiota is greatly impacted in preterm infants, who have an immature gut and are exposed to factors like hospitalization, caesarean section, antibiotics, and respiratory support.

Design

We analyzed fecal microbiota composition and activity of ten preterm infants (gestational age 25-30 weeks; birthweight 630-1750 g) during the first six postnatal weeks through metaproteomics (LC-MS/MS) and 16S-rRNA gene sequencing.

Results

A gestational-age-dependent microbial signature is observed, enabling microbiota-based differentiation

SUBMITTER: Zwittink RD 

PROVIDER: S-EPMC5587861 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature