Ontology highlight
ABSTRACT:
SUBMITTER: Dhondt I
PROVIDER: S-EPMC5587862 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Molecular & cellular proteomics : MCP 20170705 9
Protein turnover rates severely decline in aging organisms, including <i>C. elegans</i> However, limited information is available on turnover dynamics at the individual protein level during aging. We followed changes in protein turnover at one-day resolution using a multiple-pulse <sup>15</sup>N-labeling and accurate mass spectrometry approach. Forty percent of the proteome shows gradual slowdown in turnover with age, whereas only few proteins show increased turnover. Decrease in protein turnove ...[more]