Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models.

ABSTRACT:

Objective

To compare local and systemic profiles between different disease pathologies (pneumonia and encephalitis) induced by influenza A virus (IAV).

Methods

An IAV pneumonia model was created by intranasal inoculation of C57BL/6 mice with influenza A/WSN/33 (H1N1) virus. Lung lavage and blood collection were performed on day 3 after IAV inoculation. Similarly, an IAV encephalitis mouse model was created by direct intracranial IAV inoculation. Cerebrospinal fluid (CSF) and blood collection were conducted according to the same schedule. Cytokine/chemokine profiles were produced for each collected sample. Then the data were compared visually using radar charts.

Results

Serum cytokine profiles were similar in pneumonia and encephalitis models, but local responses betwe

SUBMITTER: Nagaoka Y 

PROVIDER: S-EPMC5587948 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature