Antisense RNA transcripts in the blood may be novel diagnostic markers for colorectal cancer.

ABSTRACT: Numerous genetic studies have been conducted regarding the occurrence of colorectal cancer (CRC) and the prognosis using microarrays. However, adequate investigations into the diagnostic application of microarrays have yet to be performed. The simplicity and accuracy of diagnosis and prognosis tracking are important requirements for its processes, and the use of blood cells for diagnosis is considered to be suitable to meet these requirements. The patients involved in the study were 28 preoperative patients with CRC and 6 healthy individuals who served as controls. RNA was extracted from the blood cells of the patients and analyzed using a sense/antisense RNA custom microarray. In the patients with CRC, the expression levels of 20 sense RNA and 20 antisense RNA species were identified as b

SUBMITTER: Kurokawa T 

PROVIDER: S-EPMC5587960 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature