SPEN, a new player in primary cilia formation and cell migration in breast cancer.

ABSTRACT:

Background

The primary cilium is a microtubule-based and nonmotile organelle functioning as a cellular antenna that is involved in the regulation of cell proliferation, differentiation, and migration. In breast cancer cells, the primary cilium is a structure that decreases in incidence with increasing degrees of transformation and may be biologically more important in estrogen receptor (ERα)-negative breast cancer cells. Split ends (SPEN) is an ERα corepressor that we have identified as a tumor suppressor protein in ERα-positive breast cancer cells whose hormone-independent roles in breast cancer have never been explored.

Methods

We determined the hormone-independent transcriptional program regulated by the ERα cofactor SPEN in breast cancer using DNA microarrays. The biolog

SUBMITTER: Legare S 

PROVIDER: S-EPMC5588740 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature