Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Heterozygous familial hypercholesterolaemia (FH) confers a significant risk for premature cardiovascular disease (CVD). However, the estimated prevalence of FH varies substantially among studies. We aimed to provide a summary estimate of FH prevalence in the general population and assess variations in frequency across different sociodemographic characteristics.

Setting, participants and outcome measures

We searched MEDLINE, EMBASE, Global Health, the Cochrane Library, PsycINFO and PubMed for peer-reviewed literature using validated strategies. Results were limited to studies published in English between January 1990 and January 2017. Studies were eligible if they determined FH prevalence using clinical criteria or DNA-based analyses. We determined a pooled point p

SUBMITTER: Akioyamen LE 

PROVIDER: S-EPMC5588988 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature