Conservative fluid management prevents age-associated ventilator induced mortality.

ABSTRACT:

Background

Approximately 800 thousand patients require mechanical ventilation in the United States annually with an in-hospital mortality rate of over 30%. The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and in-hospital mortality rates. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress patients, but to date there has been no investigation of the effect of conservative fluid management on VILI and ventilator associated mortality rates. We hypothesized that age-associated increases in susc

SUBMITTER: Herbert JA 

PROVIDER: S-EPMC5589142 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature