Effect of Menthol-preferring Status on Response to Intravenous Nicotine.

ABSTRACT:

Objectives

Menthol, a flavoring agent, is found in approximately 90% of cigarettes, but at much higher levels in menthol than non-menthol cigarettes. Menthol is reportedly included in cigarettes for its cooling and soothing effects, but also additional actions that affect smokers' receipt and processing of nicotine. In this study we investigated the response to short-term abstinence and acute nicotine delivery in menthol-preferring and non-menthol-preferring smokers.

Methods

Nicotine dependent participants (N = 134) participated in an intravenous nicotine delivery session following overnight smoking abstinence. Participants were intravenously administered a placebo and 2 escalating nicotine doses. We compare subjective and physiological responses to nicotine and smoking urge

SUBMITTER: DeVito EE 

PROVIDER: S-EPMC5589161 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature