Optimal Length of Conformational Transition Region in Protein Search for Targets on DNA.

ABSTRACT: The starting point of many fundamental biological processes is associated with protein molecules finding and recognizing specific sites on DNA. However, despite a large number of experimental and theoretical studies on protein search for targets on DNA, many molecular aspects of underlying mechanisms are still not well understood. Experiments show that proteins bound to DNA can switch between slow recognition and fast search conformations. However, from a theoretical point of view, such conformational transitions should slow down the protein search for specific sites on DNA, in contrast to available experimental observations. In addition, experiments indicate that the nucleotide composition near the target site is more symmetrically homogeneous, leading to stronger effective interactions b

SUBMITTER: Kochugaeva MP 

PROVIDER: S-EPMC5589516 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature