Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy.

ABSTRACT: Colorectal cancer (CRC) is prevalent worldwide, and treatment often involves surgery and genotoxic chemotherapy. DNA repair mechanisms, such as base excision repair (BER) and mismatch repair (MMR), may not only influence tumour characteristics and prognosis but also dictate chemotherapy response. Defective MMR contributes to chemoresistance in colorectal cancer. Moreover, BER affects cellular survival by repairing genotoxic base damage in a process that itself can disrupt metabolism. In this study, we characterized BER and MMR gene expression in colorectal tumours and the association between this repair profile with patients' clinical and pathological features. In addition, we exploited the possible mechanisms underlying the association between altered DNA repair, metabolism and response t

SUBMITTER: Leguisamo NM 

PROVIDER: S-EPMC5589573 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature