Profiling of metastatic small intestine neuroendocrine tumors reveals characteristic miRNAs detectable in plasma.

ABSTRACT:

Background

Current diagnostic and prognostic blood-based biomarkers for neuroendocrine tumors are limited. MiRNAs have tumor-specific expression patterns, are relatively stable, and can be measured in patient blood specimens. We performed a multi-stage study to identify and validate characteristic circulating miRNAs in patients with metastatic small intestine neuroendocrine tumors, and to assess associations between miRNA levels and survival.

Methods

Using a 742-miRNA panel, we identified candidate miRNAs similarly expressed in 19 small intestine neuroendocrine tumors and matched plasma samples. We refined our panel in an independent cohort of plasma samples from 40 patients with metastatic small intestine NET and 40 controls, and then validated this panel in a second, large

SUBMITTER: Bowden M 

PROVIDER: S-EPMC5589584 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature