Variants in the CXCL12 gene was associated with coronary artery disease susceptibility in Chinese Han population.

ABSTRACT:

Background

Coronary artery disease (CAD) is one of the most serious diseases all around the world. Previous studies have shown the function of CXCL12 in the process of atherosclerosis. The aim of this research is to examine whether variants of CXCL12 contribute to CAD.

Materials and methods

To examine whether variants of CXCL12 contribute to CAD, we selected 6 single nucleotide polymorphisms (SNPs) of CXCL12, and genotyped by Sequenom MassARRAY technology in 597 CAD patients and 685 healthy control. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age and gender. We also analysis the differences in continuous variables among the subjects with three genotypes of related genes were

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5589599 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature