Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome.

ABSTRACT:

Background

Plasma concentrations of endocan, a proteoglycan preferentially expressed in the pulmonary vasculature, may represent a biomarker of lung (dys)function. We sought to determine whether the measurement of plasma endocan levels early in the course of acute respiratory distress syndrome (ARDS) could help predict risk of death or of prolonged ventilation.

Methods

All patients present in the department of intensive care during a 150-day period were screened for ARDS (using the Berlin definition). Endocan concentrations were measured at the moment of ARDS diagnosis (T0) and the following morning (T1). We compared data from survivors and non-survivors and data from survivors with less than 10 days of ventilator support (good evolution) and those who died or needed more th

SUBMITTER: Orbegozo D 

PROVIDER: S-EPMC5589715 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature