Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model.

ABSTRACT: Obesity is associated with a high prevalence of mood disorders such as anxiety and depression. Both stress and high fat diet can alter the gut microbiota and contribute to obesity. To examine the interrelationships between obesity, stress, gut microbiota and mood disorders, obesity was induced in mice using a high fat diet, and the mice were subsequently stressed using a chronic unpredictable mild stress protocol. During the experiment, the composition of the gut microbiota was analyzed by 16 S rRNA gene high-throughput sequencing, and anxiety-like behaviors were measured. The results revealed distinct gender differences in the impacts of obesity and stress on anxiety-like behaviors, activity levels, and composition of the gut microbiota. Male mice were more vulnerable to the anxiogenic ef

SUBMITTER: Bridgewater LC 

PROVIDER: S-EPMC5589737 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature