White matter hyperintensity reduction and outcomes after minor stroke.

ABSTRACT:

Objective

To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study.

Methods

We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI. At 1 year, we assessed recurrent cerebrovascular events and dependency and repeated the MRI. We assessed change in WMH volume from baseline to 1 year (normalized to percent intracranial volume [ICV]) and associations with baseline variables, clinical outcomes, and imaging parameters using multivariable analysis of covariance, model of changes, and multinomial logistic regression.

Results

Among 190 participants (mean age 65.3 years, range 34.3-96.9

SUBMITTER: Wardlaw JM 

PROVIDER: S-EPMC5589793 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature