Longitudinal diffusion changes following postoperative delirium in older people without dementia.

ABSTRACT:

Objective

To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging.

Methods

We studied a subset of the larger Successful Aging after Elective Surgery (SAGES) study cohort of older adults (≥70 years) without dementia undergoing elective surgery: 113 participants who had diffusion tensor imaging before and 1 year after surgery. Postoperative delirium severity and occurrence were assessed during the hospital stay using the Confusion Assessment Method and a validated chart review method. We investigated the association of delirium severity and occurrence with longitudinal diffusion changes across 1 year, adjusting for age, sex, vascular comorbidity, and baseline cognitive performance. We also asses

SUBMITTER: Cavallari M 

PROVIDER: S-EPMC5589796 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature