Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography.

ABSTRACT: Diagnosis of corneal disease and challenges in corneal transplantation require comprehensive understanding of corneal anatomy, particularly that of the posterior cornea. Micro-optical coherence tomography (µOCT) is a potentially suitable tool to meet this need, owing to its ultrahigh isotropic spatial resolution, high image acquisition rate and depth priority scanning mode. In this study, we explored the ability of µOCT to visualize micro-anatomical structures of the posterior cornea ex vivo and in vivo using small and large animals. µOCT clearly delineated cornea layers and revealed micro-anatomical structures, including not only polygonal endothelial cells, stellate keratocytes, collagen fibres and corneal nerve fibres but also new structures such as the dome-shaped basolateral side of e

SUBMITTER: Chen S 

PROVIDER: S-EPMC5589810 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature