Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies.

ABSTRACT: Porcine epidemic diarrhea (PED) has caused tremendous losses to the United States pig industry since 2013. From 2014, outbreaks were also reported from Central Europe. To characterize the Central European PEDV strains regarding their virulence in suckling piglets, and to assess the protective effect of maternally derived antibodies (MDA), four trial groups were randomly assigned, each consisting of two pregnant sows and their litter. To induce MDA in a subset of piglets, two sows received a cell culture-adapted PEDV strain, and another two sows were inoculated with field material from German PED outbreaks. Four sows stayed naïve. Subsequently, all piglets were inoculated with the corresponding PEDV strains at an age of 3 to 6 days, and virus shedding, clinical signs and occurrence of speci

SUBMITTER: Leidenberger S 

PROVIDER: S-EPMC5589859 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature