Global fibroblast activation throughout the left ventricle but localized fibrosis after myocardial infarction.

ABSTRACT: Fibroblast (Fb) differentiation and interstitial fibrosis contribute to cardiac remodeling and loss of function after myocardial infarction (MI). We investigated regional presence and regulation of fibrosis in a pig MI model. In vivo analysis of regional function and perfusion defined three regions: the scar, the myocardium adjacent to the scar (MI_adjacent, reduced function, reduced perfusion reserve), and the remote myocardium (MI_remote, minimal functional deficit, maintained perfusion). Interstitial and perivascular fibrosis, and increase of collagen type I, was only observed in the MI_adjacent. Fb activated protein-alpha (FAP-α) was enriched in MI_adjacent compared to MI_remote. TGF-β1, which triggers Fb differentiation, was upregulate

SUBMITTER: Nagaraju CK 

PROVIDER: S-EPMC5589875 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature