Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.

ABSTRACT: The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating thyroid hormone levels in a narrow physiological range. As axons containing thyrotropin-releasing hormone (TRH) terminate on hypothalamic tanycytes, these specialized glial cells have been suggested to influence the activity of the HPT axis, but their exact role remained enigmatic. Here, we demonstrate that stimulation of the TRH receptor 1 increases intracellular calcium in tanycytes of the median eminence via Gα_q/11 proteins. Activation of Gα_q/11 pathways increases the size of tanycyte endfeet that shield pituitary vessels and induces the activity of the TRH-degrading ectoenzyme. Both mechanisms may limit the TRH release to the pituitary. Indeed, blocking TRH signaling in tanycytes by deleting Gα

SUBMITTER: Muller-Fielitz H 

PROVIDER: S-EPMC5589884 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature