Loss of brain inter-frequency hubs in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to analyze multiple-frequency brain networks inferred from magnetoencephalographic recordings during resting-states in AD subjects and age-matched controls. Main results showed that brain networks tend to facilitate information propagation across different frequencies, as measured by the multi-participation coefficient (MPC). However, regional connectivity in AD subjects was abnormally distributed across frequency bands as compared to controls, causing significant decreases of MPC. This effect was mainly localized in association areas and in the cingulate cor

SUBMITTER: Guillon J 

PROVIDER: S-EPMC5589939 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature