In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models.

ABSTRACT:

Objectives

The goal of this study was to develop and validate a noninvasive imaging tool to visualize the in vivo behavior of high-density lipoprotein (HDL) by using positron emission tomography (PET), with an emphasis on its plaque-targeting abilities.

Background

HDL is a natural nanoparticle that interacts with atherosclerotic plaque macrophages to facilitate reverse cholesterol transport. HDL-cholesterol concentration in blood is inversely associated with risk of coronary heart disease and remains one of the strongest independent predictors of incident cardiovascular events.

Methods

Discoidal HDL nanoparticles were prepared by reconstitution of its components apolipoprotein A-I (apo A-I) and the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine. For radiolab

SUBMITTER: Perez-Medina C 

PROVIDER: S-EPMC5589956 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature