Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC.

Methods

A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical resul

SUBMITTER: Almangush A 

PROVIDER: S-EPMC5589992 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature