Using sheep genomes from diverse U.S. breeds to identify missense variants in genes affecting fecundity.

ABSTRACT: Background:  Access to sheep genome sequences significantly improves the chances of identifying genes that may influence the health, welfare, and productivity of these animals.   Methods:  A public, searchable DNA sequence resource for U.S. sheep was created with whole genome sequence (WGS) of 96 rams.  The animals shared minimal pedigree relationships and represent nine popular U.S. breeds and a composite line.  The genomes are viewable online with the user-friendly Integrated Genome Viewer environment, and may be used to identify and decode gene variants present in U.S. sheep. Results:  The genomes had a combined average read depth of 16, and an average WGS genotype scoring rate and accuracy exceeding 99%.  The utility of this resource was illustrated by characterizi

SUBMITTER: Heaton MP 

PROVIDER: S-EPMC5590088 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature