Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.

ABSTRACT: Brain injury induces a peripheral acute cytokine response that directs the transmigration of leukocytes into the brain. Because this brain-to-peripheral immune communication affects patient recovery, understanding its regulation is important. Using a mouse model of inflammatory brain injury, we set out to find a soluble mediator for this phenomenon. We found that extracellular vesicles (EVs) shed from astrocytes in response to intracerebral injection of interleukin-1β (IL-1β) rapidly entered into peripheral circulation and promoted the transmigration of leukocytes through modulation of the peripheral acute cytokine response. Bioinformatic analysis of the protein and microRNA cargo of EVs identified peroxisome proliferator-activated receptor α (PPARα) as a primary molecular target of astroc

SUBMITTER: Dickens AM 

PROVIDER: S-EPMC5590230 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature